Still disease with persistent atypical dermatomyositis-like skin eruption: two cases associated with macrophage activation syndrome.

The typical rash of Still disease is an asymptomatic, salmon-coloured, macular, or maculopapular eruption that appears along with the fever spikes and fades when the body temperature drops. Although not included in the diagnostic criteria, there are other frequent, persistent, pruritic and polymorphic skin manifestations of Still disease that have distinctive clinical features and specific histological findings. Among these atypical persistent pruritic eruptions (PPEs), periorbital erythema and linear flagellate papules and plaques can resemble the cutaneous manifestations of dermatomyositis (DM). The presence of these lesions in adult-onset Still disease has been associated with worse prognosis and higher mortality rates, perhaps due to the development of a secondary macrophage activation syndrome (MAS). We report two cases of Still disease with persistent atypical DM-like eruption, one in a paediatric patient (a very underreported finding) and the other in an adult. Both cases developed a secondary MAS.

Bebé colodión: presentación de la ictiosis lamelar / Collodion baby: A case of lamellar ichthyosis

No disponible

Cutaneous and Mucosal Manifestations Associated with Celiac Disease.

Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.

Familial papular epidermal nevus with "skyline" basal cell layer.

Papular epidermal nevus with "skyline" basal cell layer is a variant of keratinocytic nevus that usually occurs sporadically but may affect different family members. We report on the fourth family with papular epidermal nevus with "skyline" basal cell layer affecting a 3-month-old girl and her father.

Estudio de casos y controles para evaluar el riesgo asociado de obesidad infantil y tipos de lactancia en niños de 2 a 10 años atendidos en el Instituto Nacional de Salud del Niño de Setiembre a Octubre del 2009 / Case-control study to assess the associated risk of childhood obesity and breastfeeding rates in children aged 2-10 years who presented to the National Institute of Child Health, September-October 2009

La obesidad infantil representa un problema de salud pública a nivel mundial. Entre los diversos factores a los cuales ésta se encuentra vinculada, se considera el tipo de alimentación, el cual sería una variable prevenible o modificable para evitar su desarrollo. A su vez, el tipo de alimentación en los recién nacidos se basa en la lactancia materna, siendo un aporte esencial en el desarrollo inicial de todo ser humano, si bien es cierto existen situaciones que ameritan el cambio de una lactancia materna exclusiva por una lactancia en base a fórmulas o lactancia artificial, se considera en la actualidad que una ausencia o déficit de una lactancia materna exclusiva sería per se un factor de riesgo para el desarrollo comorbilidades, pudiendose considerar dentro de estas y para este estudio, la obesidad. Se define como la lactancia materna exclusiva aquella en la cual se alimenta al nuevo ser solo con leche materna durante sus primeros 6 meses de vida, se considera que esta tiene innumerables beneficios tanto inmediatos como a largo plazo. El presente trabajo estudia la relación entre la obesidad infantil y el tipo de lactancia recibida en niños entre los dos y diez años de edad. El objetivo principal es demostrar que la lactancia artificial es factor de riesgo asociado a obesidad infantil y comprobar el efecto protector de la lactancia materna exclusiva sobre la obesidad. Se realizó un estudio de casos y controles, de diseño no experimental, retrospectivo, en base a dos poblaciones de 100 pacientes entre los dos y diez años de edad atendidos en el INSTITUTO NACIONAL DE SALUD DEL NIÑO (INSN); los pacientes incluidos en el estudio cumplieron los criterios de obesidad y eutrofismo respectivamente, según el porcentaje de medianas del CDC la clasificación de Waterloo...

Childhood obesity represents a public health problem all around the world. In between the different factors that are vinculated to this condition, there is the type of feeding which is a preventible or modifiable factor to avoid its development. Also, the type of alimentation in newborns consists in breastfeeding, which is an essential contribution in the initial development of every human been, although there are situations that warrant the change of exclusive breastfeeding for breastfeeding based on formulas or artificial feeding, is now considered that a lack or deficit of exclusive breastfeeding could be a risk factor for developing comorbidities, considering into this ones, obesity. Exclusive breastfeeding is defined as the one in wich the new human being fed only breast milk during the first six months of life, it is consider that brestfeeding have many benefits both immediate and long-term. The present work of investigation studies the association between childhood obesity and the type of lactation received in children between two and ten years old. The main purpose is to demonstrate the association between childhood obesity and artificial lactation, and to prove the protective effect of the exclusive breastfeeding lactation over obesity. The investigation consisted in a study of cases and controls; the design was not experimental and retrospective, on the basis of two poblations of one-hundred patients between two and ten years old who where attended at the INSTITUTO NACIONAL DE SALUD DEL NIÑO (INSN). The patients that where included in the study fulfilled the obesity and normal weight criteria according to percentage of medians of the CDC and tha Waterloo classification. The results were statistically evaluated according to Pearson's chi-square test...